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Numerous candidate targets have been proposed ( Table 2 ), which provide a basis for the precise application of CAR T-cell therapy.The hinge region connects the scFv to the transmembrane domain, providing structural flexibility and facilitating optimal spatial orientation between the CAR and its cognate antigen

rh IGF-1 activity is tested in human breast cancer cell line MCF-7, with Acceptance Criteria ED50 of less than or equal to 1.5 ng/mL AA Sequence GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA Alternative Names Insulin-like Growth Factor 1, somatamedin C, mechano growth factor, IGF-IA, IGF-IB, IGF-I, IGFI, insulin-like growth factor I, IGF1A1, insulin-like growth factor IA, insulin-like growth factor IB, MGF2, IBP1

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